The germinal center (GC) reaction is a key feature of adaptive humoral immunity.GCs represent the site where mature B cells refine their B-cell receptor (BCR) and are selected based on the newly acquired affinity for the antigen.In the GC, B cells undergo multiple cycles of proliferation, BCR remodeling by immunoglobulin somatic hypermutation (SHM)
Predictive maintenance is a preventive maintenance approach that is performed based on an online health assessment and allows for timely pre-failure interventions.It can diminish the cost of maintenance by reducing the frequency of maintenance as much as possible to avoid unplanned reactive maintenance, without incurring the costs associated with t
Objectives Logan local Duvet Insert government area (LGA) in Queensland has the highest diabetes prevalence (6.5%) within Metro South Health (MSH).The study aimed to determine the burden of, and equity of access to secondary healthcare, for diabetic foot disease (DFD) for Logan residents to better inform healthcare services planning.Design A retros
This paper presents a novel sustainable inventory model tailored for non-instantaneous deteriorating items, incorporating quadratic demand and time-dependent holding costs.Notably, the model Steering Wheel Products accounts for shortages over a finite time horizon, simulating real-world scenarios.The inventory management the strategy involves distr
Abstract Background Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown.Previous studies have shown that exosomes produced in the tumor microenvironment in response to chemotherapy promote a chemotherapy-resistant phenotype in tumors.However, the